To investigate this hypothesis, our laboratory has established cell culture systems using normal human preadipocytes and adipocytes that have a reduced ability to regulate energy homeostasis. These observations suggest that the activity of SRC-1 is an important component of energy homeostasis. The function of HSL is limited to the hydrolysis of triglycerides to free fatty acids and glycerol, and the availability of free fatty acids likely reflects their potential to activate SRC-1. Some aspects of this process are mediated by the interaction of hormone-sensitive lipase (HSL) with the transcription factor Steroid Receptor Coactivator-1 (SRC-1). A body’s ability to control energy homeostasis, the process by which it regulates the balance between energy intake and energy expenditure, is diminished with obesity. 26 Fire Emblem: Radiant Dawn (video game).Ĭategory: video games that support DirectXĬategory: video games developed in JapanObesity and body fat distribution are risk factors for the development of neoplastic disorders in humans.
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